منابع مشابه
OX40-OX40L interactions: a promising therapeutic target for allergic diseases?
Recent advances in understanding the cellular and molecular mechanisms of atopy have shed light on potential targets for the development of new therapies for allergic diseases. In this issue of the JCI, Seshasayee et al. provide direct in vivo evidence that OX40 has critical roles in allergic inflammation mediated by thymic stromal lymphopoietin (TSLP) (see the related article beginning on page...
متن کاملOX40:OX40L Axis: Emerging Targets for Immunotherapy of Human Disease
Recent advances in our understanding of the mechanisms through which T cells are activated have led to new therapeutic approaches in the treatment of immunological disorders. An emerging target for selective immune intervention has been the manipulation of T cell costimulatory pathways. Impressive results in animal models have shown that the tumor-necrosis-factor receptor (TNFR) family member, ...
متن کاملOX40/OX40L axis: not a friend in autoimmunity
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by a loss of tolerance toward nuclear components, and multiple organs such as kidney, brain, vessels or skin are affected. SLE presents a waxing and waning course, rendering its outcome hardly predictable. A better understanding of human SLE pathogenesis is direly needed because only few effective treatments are av...
متن کاملOX40-OX40L Interaction Promotes Proliferation and Activation of Lymphocytes via NFATc1 in ApoE-Deficient Mice
BACKGROUND Our previous studies have shown that OX40-OX40L interaction regulates the expression of nuclear factor of activated T cells c1(NFATc1) in ApoE(-/-) mice during atherogenesis. The aim of this study was to investigate whether OX40-OX40L interaction promotes Th cell activation via NFATc1 in ApoE(-/-) mice. METHODS AND RESULTS The lymphocytes isolated from spleen of ApoE (-/-) mice wer...
متن کاملAirway Wall Expression of OX40/OX40L and Interleukin-4 in Asthma
BACKGROUND The costimulatory molecule OX40 and its ligand, OX40L, mediate key aspects of allergic airway inflammation in animal models of asthma, including eosinophilic airway inflammation, airway hyperresponsiveness, and T helper 2 polarization. We sought to examine OX40/OX40L and interleukin (IL)-4 expression in asthma across severities. METHODS Bronchial biopsies were obtained from 27 subj...
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ژورنال
عنوان ژورنال: Developmental & Comparative Immunology
سال: 2018
ISSN: 0145-305X
DOI: 10.1016/j.dci.2018.01.014